Gholizadeh Ghaleh Aziz, SH and Khalaji, N and Naderi, R and Mahmodian, N (2018) Tropisetron ameliorates oxidative stress in type-1 diabetic experimental rats. International Journal of Research in Applied and Basic Medical Sciences, 4 (2). pp. 102-107.
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Abstract
In this study, we evaluated the effect of tropisetron on the oxidative biomarkers in the plasma of type 1 diabetes mellitus (DM). Twentyone male Wistar rats were randomly divided into three experimental groups (n =7): control, diabetic and diabetic + tropisetron. Diabetes type 1 was induced by streptozotocin (STZ) (50 mg/kg; i.p). Tropisetron (3 mg/kg; i.p) as a 5-HT3 antagonist was given once daily for 2 weeks. At the end of experiment animals were euthanized and blood samples were collected for further analysis including superoxide dismutase (SOD), glutathione peroxidase (GPx) activities and malondialdehyde (MDA), total antioxidant capacity (TAC) levels. We found that tropisetron attenuated MDA levels and increased SOD, GPx and TAC contents in the plasma of diabetic rats. Our findings indicate that tropisetron improved oxidative stress in the plasma of STZ induced-diabetic rats
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Diabetes, Tropisetron, Oxidative stress, Rat |
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Unnamed user with email gholipour.s@umsu.ac.ir |
| Date Deposited: | 03 Mar 2019 07:50 |
| Last Modified: | 03 Mar 2019 07:50 |
| URI: | http://eprints.umsu.ac.ir/id/eprint/5453 |
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