THE EFFECT OF FOUR WEEKS' VOLUNTARY EXERCISE ON A REGULAR AND COMPLEX WHEEL RUNNING ON NG2 BRAIN LEVELS IN HEALTHY MALE WISTAR RATS

Ahmadi Bandar Khili, F and Fallah Mohammadi, Z (2019) THE EFFECT OF FOUR WEEKS' VOLUNTARY EXERCISE ON A REGULAR AND COMPLEX WHEEL RUNNING ON NG2 BRAIN LEVELS IN HEALTHY MALE WISTAR RATS. The Journal of Urmia University of Medical Sciences, 29 (12). pp. 896-903.

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Abstract

NGF-2 is oligodendrocyte progenitor cell which has neuroprotective functions. This study was designed to investigate and compare the effect of a 4-week voluntary training program on regular and complex running wheels on NGF-2 levels in healthy Wistar male rats. Materials and methods: Thirty adult Wistar male rats were divided into 3 groups: voluntary training on regular running wheel, voluntary training on complex running wheel, and control. For measuring the NGF-2 levels in the brain, the ELISA test was used. One-way analysis of variance and Tuckey post-hoc tests were employed for comparing the intergroup differences. All the statistical analysis were conducted by SPSS software (version 20). Results: Performing voluntary training programs on regular (p=0.03) and complex running wheels (p=0.001) resulted in significant changes in NGF-2 levels in the brain. There was also a significant difference between these two modes of training programs (p=0.05). Conclusion: Based on the results, these 2 training protocols can be regarded as positive intervening factors for increasing oligodendrocytes in healthy rats, although the complex running wheel voluntary training has shown to be more promising.

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