Ahmadi Shadmehri, A and Miri, H.R and Namvar, F and Nakhaei Moghaddam, M and Yaghmaei, P (2019) Cytotoxicity, Antioxidant and Antibacterial Activities of Crocus Sativus Petal Extract. International Journal of Research in Applied and Basic Medical Sciences, 5 (1). pp. 69-76.
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Abstract
Crocus Sativus Petals are a dusted waste that contains bioactive compounds. The aim of this study was to evaluate the cytotoxicity, antioxidant, antibacterial activities of Crocus Sativus petals extract (CSPE). The cytotoxic effects of CSPE on human liver cancer cells (HepG2) were performed using MTT assay. Then, cell morphology was determined by inverted microscope. The antioxidant activity of CSPE was evaluated using DPPH and ABTS assays. Antibacterial activity of CSPE was tested against gram-negative bacteria Escherichia coli (E. coli) and gram positive bacteria staphylococcus aureus (S. aureus) using macrodilution method. CSPE inhibited the proliferation of the HepG2 cell line in a time and dose-dependent manner, which was consistent with morphological changes. Extract showed the enhanced antioxidant properties and also were found effective against the bacterial strains. Due to the antiproliferative, antioxidant, antibacterial effects of CSPE, it can be used in pharmaceutical industry, including the production of anticancer, antioxidants and antibacterial drugs
| Item Type: | Article |
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| Uncontrolled Keywords: | Crocus Sativus petal extract, HepG2, antioxidant activity, antibacterial activity, pharmaceutical industry |
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Unnamed user with email gholipour.s@umsu.ac.ir |
| Date Deposited: | 04 May 2019 07:18 |
| Last Modified: | 04 May 2019 07:18 |
| URI: | http://eprints.umsu.ac.ir/id/eprint/5522 |
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