Ahmadi Shadmehri, A and Darbouy, M and Tabatabaiefar, M.A and Tavakkoly Bazzaz, J (2020) A 15; 15 Translocation in a couple with Repeated Abortions: Case Report. International Journal of Research in Applied and Basic Medical Sciences, 6 (1). pp. 14-17.
|
Text
3 Ahmadi Shadmehri A-10-106-1.pdf Download (849kB) | Preview |
Abstract
Carriers of structural chromosomal rearrangements such as Robertsonian or reciprocal translocations have an increased risk of spontaneous abortion and producing offspring with genetic abnormalities. Robertsonian translocations are present in 0.1% of the general population and 1% of the infertile population. Two types of Robertsonian translocations occur more frequently than all others, being 45,XX,rob(13;14)(q10;q10) and 45,XX,rob(14;21)(q10;q10) respectively. The history of repeated abortions could be the outcome of unbalanced gametes (either monosomy or trisomy) resulting during the meiotic segregation of the balanced heterozygote female carrier. In the present report, uncommon Robertsonian translocation in a couple with spontaneous repeated abortions is reported. Cytogenetic analysis of a couple revealed the presence of 45, XY, t (15; 15) (10q; 10q) chromosomal constitution in the male partner. The cytogenetic analysis of couples with repeated abortions is obligatory to identify any probable chromosomal aberrations. As far as we know this is the first instance reported in Iran.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Carrier, Chromosomal rearrangements, Robertsonian translocations, Abortion |
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Unnamed user with email gholipour.s@umsu.ac.ir |
| Date Deposited: | 07 Sep 2019 05:24 |
| Last Modified: | 07 Sep 2019 05:24 |
| URI: | http://eprints.umsu.ac.ir/id/eprint/5647 |
Actions (login required)
 |
View Item |
