Soleimany, A and Seyed Mohammadzad, M.H and Khanahmadi, SH and Khadem Vatani, K and Hajizadeh, R (2020) EVALUATION OF SERUM KLOTHO LEVEL IN PATIENTS WITH AND WITHOUT CORONARY ARTERY DISEASE. Studies in medical sciences, 31 (3). pp. 178-187.
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Abstract
Serum Klotho is suggested to have a protective effect against cardiovascular diseases. Nitric oxide production and preventing oxidative stress have been suggested as its possible mechanisms of action. In this study, we aimed to evaluate the association between serum Klotho level and cardiovascular diseases. Materials & Methods: According to coronary angiography results, 40 patients with a normal coronary artery and 40 patients with coronary artery disease were included in this study. Serum Klotho level and laboratory data were analyzed for each patient and the association between serum Klotho level and coronary artery disease was evaluated. Results: Our results showed that Serum Klotho level in patients with 1 vessel, 2 vessels, and 3 vessels disease was 2.16 0.2, 2.2 0.13, 1.98 0.2 mIU/L, respectively. (p =0.02) The plasma Klotho concentration was significantly lower in patients with coronary artery disease. Conclusion: Serum Klotho level can be a useful marker for the evaluation of patients with coronary artery disease.
| Item Type: | Article |
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| Uncontrolled Keywords: | Klotho, Severity of CAD, cardiovascular risk factors |
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Unnamed user with email gholipour.s@umsu.ac.ir |
| Date Deposited: | 04 Jul 2020 05:15 |
| Last Modified: | 04 Jul 2020 05:15 |
| URI: | http://eprints.umsu.ac.ir/id/eprint/5975 |
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