Davar, S and Mahdi Akhgar, M and Saei, S and Mohammad Rahimi, M (2020) Effect of sirolimus as an immunosuppressive agent on kidney transplantation in patients with diabetes mellitus; a systematic review. Journal of Nephropathology, 9 (2). e13-e18.
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Abstract
Sirolimus is a macrolide and a type of immunosuppressant drug to prevent rejection of transplanted organs. Tis drug inhibits the activation of T and B lymphocytes and reduces the production of interleukin-2 (IL-2). Tis study aimed to review the effect of sirolimus in kidney transplantation in patients with diabetes mellitus as a systematic review. Materials and Methods: International databases including PubMed, Web of Science and Scopus were considered for search of English articles by 29 June 2019. Twenty-one published articles were fnally entered into the study. Keywords were sirolimus, rapamune, rapamycin, diabetes mellitus and kidney transplantation or a combination of them in the title/abstracts. Treatment using a combination of sirolimus and tacrolimus were excluded. Results: Tere were more than 3244 research units reviewed in this systematic review of 21 published articles. Conclusion: According to the results, sirolimus-based immunosuppression for preventing kidney transplantation is effective and has a low-risk in diabetic patients resulting in suitable glucose control
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Sirolimus Diabetes mellitus Kidney transplantation End-stage renal disease |
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Unnamed user with email gholipour.s@umsu.ac.ir |
| Date Deposited: | 12 Sep 2020 04:53 |
| Last Modified: | 12 Sep 2020 04:53 |
| URI: | http://eprints.umsu.ac.ir/id/eprint/6015 |
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