Evaluation of antiphospholipid antibodies and activated partial thromboplastin time in women with adverse outcome of pregnancy

Adverse outcome of pregnancy is a potentially dangerous
complication of conception and affects 15-20% of pregnancies.
According to recent studies increased level of blood
antiphospholipids antibodies, if accompanied by predisposing
factors, can be an adverse event in human pregnancy.
The aim of the present study was to compare the maternal
serum levels of anticardiolipin and antiphosphatidyl serine,
and partial thromboplastin time between patients with adverse
outcome of pregnancy and matched subjects with normal
pregnancy. Serum levels of anticardiolipin and antiphosphatidyl
serine and activated partial thromboplastin time
were measured in 150 women with adverse pregnancy outcome
and 150 matched women with normal pregnancy after
a gestational age of 10 weeks. Data on maternal age, age of
pregnancy, serum levels of anticardiolipin and antiphosphatidyl
serine, and activated partial thromboplastin time
were collected and compared by Student’s t or χ 2 tests. The
age of mothers in the two groups were 25.86±5.90 and
27.09±5.63 years (P=0.67), and the age of pregnancies were
29.34±5.12 and 28.17±7.03 (P=0.1) weeks in the control and
patient groups, respectively. Positive levels of serum anticardiolipin
and antiphosphatidyl serine antibodies, and activated
partial thromboplastin time for the control and patient groups
were 14.3% versus 85.7% (P=0.002), 15.2 % versus 84.8 %
(P=0.003), and 23.1 % versus 76.9% (P=0.001), respectively.
The findings suggest that positive levels of serum antiphospholipids
are associated with adverse outcome of pregnancy
in the study population.