Jamali, A and Roostaee, M.H and Soleimanjahi, H and Ghaderi Pakdel, F and Bamdad, T (2007) DNA vaccine-encoded glycoprotein B of HSV-1 fails to protect chronic morphine-treated mice against HSV-1 challenge. Comparative Immunology, Microbiology and Infectious Diseases, 30 (2). pp. 71-80.
DNA_vaccine-encoded_glycoprotein_B_of_HSV-1-2007.pdf
Download (136kB) | Preview
Abstract
The use of morphine has been demonstrated to increase susceptibility to infections. Herpes
simplex virus type 1 (HSV-1) is a highly successful pathogen among immunocompromised
individuals. In the present study, due to the importance of HSV vaccination in morphine
abusers, the effects of chronic morphine exposure on the host response to a HSV-1 gB DNAbased
vaccine have been investigated. The study is addressing an important aspect of vaccine
development among the susceptible (immunocompromised) hosts. BALB/c mice were exposed
to morphine over 11 days. They were then vaccinated with DNA vaccine or KOS strain as a
live vaccine. The findings showed that the morphine-treated animals failed to respond to DNA
vaccination evaluated by the anti-HSV gB antibody titer, delayed type hypersensitivity (DTH)
and lethal HSV-1 challenge. Under the same conditions, the KOS vaccine showed a reduced
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 12 |
| Uncontrolled Keywords: | Morphine; Herpes simplex virus; DNA vaccine |
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Unnamed user with email gholipour.s@umsu.ac.ir |
| Date Deposited: | 19 Aug 2017 09:06 |
| Last Modified: | 16 Feb 2019 10:48 |
| URI: | https://eprints.umsu.ac.ir/id/eprint/1408 |
Actions (login required)
- View Item