Zaidali, S and Safinejad, K and Galehdari, H (2017) ASSOCIATION STUDY OF THE RS6062314 POLYMORPHISM IN THE TNFRSF6B GENE IN MEN POPULATION WITH SPORADIC MULTIPLE SCLEROSIS IN KHUZESTAN PROVINCE. The Journal of Urmia University of Medical Sciences, 27 (10). pp. 856-862.
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Abstract
Multiple Sclerosis (MS) is an autoimmune, demyelinating and neurodegenerative
disease of the central nervous system (CNS). The pathogenesis of this disease is still unknown, although
there are evidences of environmental factors affecting subjects with genetic predisposition factors.
TNFRSF6B protein in human is coded by the tnfrsf6b gene. One of the biological functions of
TNFRSF6B is that it acts as death decoy and prevents cell death under certain circumstances. Some
examples of studies have shown that rs6062314 (tnfrsf6b) polymorphism is associated with risk of MS.
The aim of this study was to investigate the association of rs6062314 polymorphism in tnfrsf6b gene in
men population with sporadic multiple sclerosis in Khuzestan province.
Materials & Methods: The type of study was case-control and 100 unrelated subjects including 50
patients with low and moderate levels of MS (EDSS ≤ 3) and 50 healthy men were enrolled and
molecular techniques were used; in addition, extraction of DNA, PCR, and direct sequencing were
studied.
Results: The genotype and allele frequencies of rs6062314 (tnfrsf6b) between MS patients and controls
did not differ significantly (P-value=0.268 and P CC=1.0 and OR = 3.128, 95% CI = 0.61-15.89 for C
allele).
Conclusion: Our results showed that there was no association between rs6062314 (tnfrsf6b) SNP
polymorphism and MS disease.
Item Type: | Article |
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Uncontrolled Keywords: | Multiple Sclerosis, rs6062314 polymorphism, tnfrsf6b gene, Khuzestan |
Subjects: | R Medicine > R Medicine (General) |
Depositing User: | Unnamed user with email gholipour.s@umsu.ac.ir |
Date Deposited: | 20 Sep 2017 08:48 |
Last Modified: | 30 Jun 2019 05:53 |
URI: | https://eprints.umsu.ac.ir/id/eprint/2971 |