EFFLUX PUMP INHIBITORS EFFECT ON THE MINIMUM INHIBITORY CONCENTRATION OF BENZALKONIUM CHLORIDE AND CHLORHEXIDINE IN ACINETOBACTER BAUMANNII STRAINS ISOLATED FROM HOSPITALIZED INPATIENTS IN GAZI HOSPITAL, ANKARA

Today, increasing resistance to antibiotics causes serious problems for treatment
of patients. The aim of this study was to determine the role of AdeABC efflux pump in the Benzalkonium
chloride and Chlorhexidine MIC value with efflux pump inhibitors (1-1-naphthylmethyl-piperazine and
phenyl-arginine-β-naphthylamide) in the A.baumanii strains isolated from intensive care unit.
Materials & Methods: This study was conducted on 50 isolates of Acinetobacter baumannii collected
from ICU wards of Gazi hospital. The species identification was performed by standard laboratory
methods. Benzalkonium chloride and Chlorhexidine MIC value were performed using microdilution
method according to the clinical and laboratory standards institute (CLSI) guidelines. The activity of the
efflux pump was evaluated using the efflux pump inhibitors.
Conclusions: The AdeABC efflux pump may play a role in decreasing Benzalkonium chloride and
Chlorhexidine MIC value in A. baumannii isolates