THE EFFECTS OF INTERVAL COMBINED ENDURANCE TRAINING ON SOME KEY REVERSE CHOLESTEROL TRANSPORT FACTORS IN BOY ADOLESCENTS

ABCA1 as a member of the ABC transporters family plays a crucial role in
RCT, HDL-C formation andultimatly CAD prevention. The purpose of this study was to investigate
ABCA1 expression in lymphocytes, plasma apolipoprotein A-I and lipid profiles in response to eight
weeks interval combined endurance training (ICET) among overweight and obese boy adolescents.
Materials & Methods: This study was conducted on 28 healthy overweight and obese male
adolescents (17.1 ± 1.08 yr, 89.91 ± 9.98 kg and 28.32 ± 2.55 kg / m²) who volunteered and were
randomly assigned into training (n = 13) and control (n = 15) groups. Exercise protocol was ICET
(8WK, 4 d/wk, 70 min/d). Cell hemolysis and sensitive Elisa method was used for Lymphocyte
ABAC1 measurement. The Student's t-test and SPSS16 were employed for data analysis.
Results: The results showed that in post-exercise the amounts of ABCA1 and VO2 max significantly
increased and TC,TG, LDL-c/HDL-c, TC/HDL-c, and PBF, WC and BMI significantly decreased
(p<0.05). Changes in other variables such as ApoA-I, HDL-c, LDL-c, and body weight were not
significant (p>0.05).
Conclusion: It seems that ICET can have positive effects on ABCA1 (as important factor RCT) and
some lipid and physiological indicators and ultimately in prevention of arteriosclerosis in overweight
and obesity of adolescents