EFFECT OF DILL (ANETHUM GRAVEOLENS L) ETHANOL EXTRACT ON PAIN AND MORPHINE-INDUCED ANALGESIA IN MALE MICE

Due to the side effects of chemical drugs and their expensive prices, nowadays
medicinal plants are of great interest, and dill is one of these plants. The aim of the present study was
evaluating analgesic effect of dill ethanol extract in male mice by using formalin test in the presence
and absence of intravenous morphine.
Materials & Methods: In this study, 28 mice were used and divided into 4 groups of control, morphine
(positive control), dill, and dill+ morphine. Ethanol extract of dill, 500 milligrams per liter in drinking
water for 30 days was given to the animals. In positive control group, 10mg/kg of morphine was
injected with a single dose subcutaneously. Pain scores obtained using formalin test with injection
0.02 ml of formalin 5% to the fourth finger of the animals’ right hand.
Results: The results of this study showed that dill ethanol extract by oral administration method
decreased pain scores in the acute and chronic phases of formalin-induced pain. Concurrent using of
ethanol extract of dill and morphine had dramatic analgesic effect.
Conclusion: The results of this study confirm that compounds present in dill have analgesic effects
and also increase the analgesic effects of morphine