EVALUATION OF THE ASSOCIATIONS BETWEEN THE SEVERITY OF CORONARY HEART DISEASE AND SERUM LEVELS OF URIC ACID OR FETUINA UNDERGOING CORONARY ANGIOGRAPHY

It has been proposed that uric acid (UA) and FetuinA (FA) are independent risk
factor for the development of cardiovascular disease (CAD). UA is the end-product of purine
metabolism and is considered an endogenous antioxidant. FA is a protein secreted by the liver; acting
as an inhibitor of coronary artery calcification. The aim of the present investigation was to survey the
association between severity of CAD and sera UA or FA.
Materials & Methods: Subjects (n=83) undergoing coronary angiography were enrolled. According to
angiographic results, the subjects were divided into: Control (CTL; n=21; age 55±8.9 years), one
vessel obstruction (1VD; n=20; 57±10.1 years) and multi-vessel obstruction (Multi VD; n=42;
65.4±9.7 years). FA level were determined by ELISA. Clinical biochemical parameters were assayed
by routine laboratory methods. Statistical analyses were performed using SPSS package (version 22).
Results: Serum UA levels in multi VD and 1VD were higher than that of CTL group (P=0.05). FA
levels slightly declined with the severity of CAD (P=0.23). Multi-regression analysis revealed that
age, BMI, HDL-C, glucose and Hb were associated with the severity of CAD. It was also found that
UA is independent for the prevalence of CAD.
Conclusions: Considering the small sampling size, this study demonstrates that increasing UA levels
is associated with the severity of CAD and is an independent risk factor for the occurrence of CAD.
Regarding the impact of FA on the severity of CAD, further studies with larger sample size and the
implementation of a scoring system for degree of artery calcification are deemed necessary