HEALING EFFECT OF INDUCTION OF DIRECT ELECTRIC CURRENTS PLUS SELENIUM AND SILVER NANOPARTICLE ON SKIN LESIONS CAUSED BY LEISHMANIAL MAJOR IN BALB/C MICE

Various Leishmania species can cause human infection with a spectrum of clinical
manifestations. The current treatments are unsatisfactory; and in absence of a vaccine there is an urgent
need for effective drugs to replace those currently in use. In the present study, the effect of direct current
electricity in combination with selenium and silver nanoparticles on the healing of leishmanial lesions
has been investigated.
Materials & Methods: In this experimental study, 24 Balb/c mice were divided into four groups and
infected experimentally with L.major. Then silver nanoparticles with a concentration of 250 mg/kg and
selenium nanoparticle with a concentration of 125 mg/kg were injected inter-lesion, and simultaneously
0.5 mA DC induction was applied directly into the wound. Finally, the lesion size and mice body weight
changes were measured during five weeks.
Results: The lesions were found to be smaller in the group treated with DC and silver nanoparticles than
the group treated with DC and selenium nanoparticles (P < 0.05). Two treated groups showed significant
differences with both negative control group and the group treated with Glucantime (P < 0.05).
Conclusion: The results showed that selenium and silver nanoparticles with direct current electricity
promotes wound healing in mice