POLYMORPHISM OF 1691G> A, V COAGULATION FACTOR GENE IN THE HEALTHY POPULATION OF EAST AZERBAIJAN PROVINCE OF IRAN

Genetic mutation, 1691G> A common polymorphism in a gene that is inherited
coagulation Factor 5 is associated with increased risk of thrombosis. This mutation in different
populations can develop in the prognosis of thrombotic disorders, cardiovascular disorders; recurrent
miscarriage and other thrombotic factors are useful. Study using appropriate strategies such as review of
medical and epidemiological information will be helpful for future studies.In this study, the frequency of
the mutation 1691G> A in the gene for clotting factor 5 in a healthy population of East Azerbaijan
province was investigated.
Materials & Methods: This study was conducted on 200 normal individuals with no history of
cardiovascular disease by eliminating patients with a history, as an example of Northwest's population.
After obtaining blood and ARMS-PCR to determine the frequency of alleles with G1691A, mutation of
coagulation factor 5 was attempted.
Results: The frequency of G allele in 86% of females and males was 91%, while the A allele frequency in
females and 14 males was 9%. Allelic frequency of G>A mutation in factor V for GG, GA and AA
genotypes were 0.94, 0.06 and 0, respectively.
Conclusion: In our country, according to several ethnic members including a variety of native Persians,
Turks, Kurds, Lors, Baluchis, Arabs, Bakhtiari, Turkmen, and Armenians, the allele frequencies for
Factor 5 Leiden part of the region Ethnicity is a different disease.