THE EFFECT OF LONG PERIOD OF REGULAR EXERCISE ON LIPID PROFILES AND SVCAM-1, SICAM-1 CHANGES IN OBESE WOMEN

Based on research evidence prevalence of cardiovascular disease has
inflammatory background and general inflammation (systemic) plays an important role in
atherosclerosis progressing. These factors may increase the risk of such diseases particularly in
overweight and obese men. The purpose of this study was to investigate long-term effects of regular
exercise on lipid profile changes and sVCAM-1, sICAM-1 accumulation in obese women.
Materials & Methods: 36 healthy women participated in this study and randomly assigned to both
exercise ( and 18 patients with an average age of 32± 41/2 years, BMI 34 ± 48/1 (kg/m2)) and control
groups (n = 18 mean age, 32 ± 23/1 years, BMI 34/06 ± 24/03 (kg/m2)) respectively. Exercise
program involved a 12-week training with intensity of 65-75% of maximum heart rate done three days
per week in one session of 55-60 minute period. Serum levels of sVCAM-1, sICAM-1 evaluated by
enzymatic Immunosorbent (Aymvnvzvrbnt) method using ELISA kits of BMS232 companies and
BMS232TEN from Netherland. Also hs-CRP evaluated by immunoturbidometry method. Lipid
profiles includes: low-density lipoprotein (LDL-C), high density lipoprotein (HDL-C), total
cholesterol and triglycerides evaluetad by photometry and anthropometric indices and body
composition were measured in pre and prostrating times. Data analysis was done on P<0.05 using
SPSS.
Results: According to our findings after 12 weeks of training, there was significant differences in
levels of sICAM-1andsVCAM-1, hs-CRP, TG, TC, LDL-c, HDL-c, LDL / HDL, TC / HDL between
experiment and control groups. Also WHR, BMI and body fat percent was significantly reduced in the
experimental group.
Conclusion: Regular exercise with reducing of inflammatory markers such as: sICAM-1, sVCAM-1,
LDL-c, TG, TC may have a role in prevention and controlling of cardiovascular diseases. Also
according to this fact that sICAM-1, sVCAM-1 are more sensitive indices than other lipid profiles,
accurate measurement of those appears reasonable for detecting risk factors of heart disease.