EFFECT OF ORAL RITODRINE ON IMPLANTATION RATE OF IN VITRO FERTILIZATION-EMBRYO TRANSFER CYCLES

Infertility is a common problem in young couples and affects approximately 10-
15% of them. Assisted reproductive methods are known techniques which are rapidly progressing.
One of the factors involved in embryo implantation failure is uterus contraction stimulus during
embryo transfer into the uterine that may be avoided by using ritodrine in this period
Materials & Methods: In a randomized clinical trial, we studied 200 women with infertility that were
candidate for IVF/ICSI and achieved inclusion criteria in the form of two interventions and control
groups (100 patients in each group).We evaluated the effect of oral ritodrine on fetus implantation in
patients under treatment with IVF-ET method.
Results: The mean age of the patients was 30.9±4.2 years in range of 20 to 42 years. The percent of
fertilization in group under treatment with ritodrine was 73.2±15.8 and this value was 72.6±17.6 in
control group, there was no significant difference between the two group from this point of view
(P=0.61).The oocytes and transferred fetus was not significantly different in two groups (P=0.48,
P=0.51 respectively). Successful pregnancy rate was 27% in the intervention group and 19 percent in
control group which the difference was not statistically significant between the two groups (P=0.12).
Conclusion: With regard to the findings of the present study and considering the indifferent successful
pregnancy rates between the two groups we can conclude that implantation in the IVF-Et method is
not influenced by ritodrine alone. More studies with more cases are recommended.