DETERMINATION OF DEXTROMETHORPHAN IN PHARMACEUTICAL FORMULATIONS AVAILABLE IN DRUG MARKET OF IRAN USING HPLC METHOD

Quality control is the most common function to test and measure material and
product. Quality control of active ingredients in drug formulation is to control the quality of the
products of a company and evaluate their stability. The purpose of this study was to determine the
amount of dextromethorphan available in drug market of Iran.
Materials & Methods: For this purpose different pharmaceutical formulations of dextromethorphan
with different serial number preparations were purchased from the market. Based on their standard
methods of extraction (USP Pharmacopeia) the active ingredient dextromethorphan was extracted and
determined by using HPLC Colum. The method utilize fluorescence detector.
Results: The results of this project on 40 commercial products were as follow: The respective forms of
pharmaceutical tablets were 104-124%; drops 87-92%; simple syrup 91-119%; and syrup mixture 109-
120% of labeled.
Conclusion: The assay results obtained from forty commercially available formulations of tablet and
syrup were more than the amounts declared which agree with the tolerances indicated by the USP
pharmacopeia while the assay results for drops were less than the declared values.