CORRELATION BETWEEN EMBRYO IMPLANTION AND FOLLICULAR FLUID SELECTED CYTOKINES AND HORMONE LEVELS IN WOMEN UNDER TREATMENT BY MICROINJECTION TECHNIQUE

Concentrations of certain substances in follicular fluid (FF) may related to
fertilization outcome. The study aim was to identify FF markers with which to predict embryo
implantation potential.
Materials & Methods: Concentrations of selected hormones, cytokines and growth factors in FF
samples obtained during assisted reproduction treatment, Intracytoplasmic Sperm Injection (ICSI)
method were related with treatment outcomes.
Results: Mean concentrations of 17beta-estradiol (E2), prolactin (PRL) and insulin-like growth factor
(IGF)-I were significantly higher, in treatment attempts leading to a clinical pregnancy as compared
with those in which no pregnancy was established. LH, growth hormone (GH), progesterone, and
interleukin-1 (IL-1) concentrations are similar in successful and unsuccessful attempts.
Conclusions: Fertilization outcomes were related to FF levels of PRL, E2 and IGF-I. But LH, growth
GH, progesterone, and IL-1 are not markers of success.