STUDY OF INFLAMMATORY MARKERS IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE PATIENTS

chronic obstructive pulmonary disease (COPD) is characterized by irreversible airflow
obstruction. Many of the systemic manifestations of chronic obstructive pulmonary disease are
mediated through increased systemic levels of inflammatory proteins. Oxidative stress and
inflammation are the major hallmarks of COPD and inflammatory factors can be used as a biomarker
to assess the risk of this chronic disease. This study was designed to evaluate some inflammatory
factors in COPD patients.
Materials and Methods: We assessed inflammatory factors (Interleukin-6, C-reactive protein and
fibrinogen) in 29 COPD patients, 29 smokers (S) and 29 non-smoker (NS) subjects. Interleukin-6 and
CRP was assessed using ELISA Kit and fibrinogen was assessed using coagulation Clauss method.
Results: Fibrinogen level were significantly higher in COPD patients compared to healthy smokers
and healthy non smokers (p<0.05). Measurement of hsCRP and IL-6 levels showed significant
increase in COPD patients compared to the healthy smokers and healthy non smokers (P<0.001).
Conclusions: The obtained data in this study indicated presence of inflammation and oxidative stress
in COPD patients. To reduce complications of this disease, consumption of antioxidant compounds
and avoiding exposure to oxidizing agents such as cigarette smoke and environmental pollutants are
recommended. However more studies are required to reveal the effect of these factors