THE CORRELATION BETWEEN ERADICATION OF HELICOBACTER PYLORI AND IMPROVEMENT SYMPTOMS BY FOUR DIFFERENT REGIMES IN PATIENTS WITH CHRONIC DYSPEPSIA.

Chronic dyspepsia is associated with Helicobacter pylori infection and motility disorder.�Whether curing the infection actually improves the symptoms or no , remains highly controversial.�In this study, we compared four regimes for eradication of H. pylori and its results on improvement of gastrointestinal symptom.

Materials & Methods : This was a clinical trial which was performed on 160 volunteers from May 2007 to May 2008. Sixty five of them were excluded from our study. Using GIS score, each patient was given a score. In patients with positive Rapid Urease Test, we started the H. Pylori treatment by four regimes (triple therapy for 7 or 10 days, quadruple therapy for 1 or 3 days). The success of the treatment was confirmed by UBT test. In each group the response to treatment was recorded.

Results : Among 95 cases in this stud y, 10.5 % of the patients received quadruple therapy for one day, 22.1% for 3 days, 42.1% received triple therapy for 7 days, and 25.3% for 10 days. The eradication of H. Pylori was confirmed in 64.3% of the cases by UBT (after 6 weeks). The rate of eradication in 7 and 10 day regimes were 70% and 79.2% and in one and three days regimes were 30% and 61.9% respectively (P=0.041%). The mean GIS recovery score before and after treatment was significant (p=0.03).

Conclusion : Although GIS score improvement didn't differ significantly in different therapeutic regimes, the best symptom improvement was recorded for patients with successful eradication.