RELATIONSHIP BETWEEN HIGH RISK OCCUPATION PARTICULARLY AROMATIC AMINES EXPOSURE AND BLADDER CANCER IN ISFAHAN: A CASE – CONTROL STUDY.

This study investigated different causes of bladder cancer. We followed two chief objectives first to identify high-risk occupations in Isfahan and second to re-inspect occupations that were in relation with bladder cancer.

Materials & Methods : In this cross control study, 300 bladder cancer cases and 500 hospital controls were interviewed. The cases and controls were matched for age and sex and demographic information, occupational history and exposure history to the chemical compounds such as aromatic amines were collected. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were calculated by unconditional logistic regression for each occupation.

Results : After grouping job titles based on international standard classification of occupations (ISCO-08) , there was a significant association for increased risk of bladder cancer among truck and bus drivers (OR=11.3) , farmers (OR=6.04), Metal industry workers(OR=6), domestic housewives (OR=5.9), and construction workers (OR=3.8),. There was no significant relation ship between bladder cancer in workers and textile, paint, rubber, print, leather and shoe.

Conclusions : Truck and bus drivers , farmers, metal industry workers, domestic wives, and construction workers demonstrated a major association between occupation and elevated risk of bladder cancer. The findings of this investigation should be tested in the future studies, in particular since exposures to agents such as cutting fluids or aromatic amines in metal industry workers and farmers.