CHANGES FIBRINOLYSIS FACTORS OF OVERWEIGHT AND OBESE POSTMENOPAUSAL WOMEN IN RESPONSE TO AEROBIC TRAINING

Obesity and menopause both increase the risk of cardiovascular diseases,
associated with fibrinolysis capacity reduction. Aerobic training is associated with reduction risk of
cardiovascular disease, but the role of aerobic training on tPA and PAI-1 as main regulators of
fibrinolysis system in obese postmenopausal women is not understood. The aim of this study was to
investigate the effects of aerobic training on fibrinolysis factors in overweight and obese
postmenopausal women.
Materials & Methods: A number of twenty four overweight and obese postmenopausal women (age:
53.61±5.02 yrs, weight: 74.95±7.74kg and BMI: 30.56±3.43 kg/m2) were randomly divided into two
groups including Aerobic Training (n=12) and Control (n=12). Aerobic training group was trained 3
sessions/wk for eight weeks at 60-75% of max reserve heart rate for 30-60 minutes. Blood samples were
collected at baseline as well as 48 hrs after the last training session, followed by measuring tPA and
PAI-1 plasma levels by ELISA. Dependent and independent T-tests have used to data analysis, the level
of significance has been consider at P≤0/05.
Results: Data analysis showed, aerobic training significantly reduced the plasma level of PAI-1
(p≤0/05), however, there were no effects on tPA (P>0/05). Also, aerobic training reduced triglycerides,
LDL and increased HDL (p≤0/05), but there were no effects on cholesterol tom (P>0/05).
Conclusion: Moderate-intensity aerobic training plays an important role in reducing PAI-1 and lipid
profile in overweight and obese postmenopausal women, however, it seems it does not influence on
variations of plasma tPA