THE EFFECT OF COMBINED ATORVASTATIN AND ZINC SULFATE ON SERUM LEVELS OF GLUCOSE AND LIPIDS IN TYPE I DIABETIC RATS

Diabetes is the most common endocrine disease associated with impaired glucose
and lipid metabolism. The aim of this study was to evaluate the effects of combined atorvastatin and
zinc sulfate on blood glucose and lipids in diabetic rats.
Materials & Methods: One control group (group NC) and four diabetic groups as diabetic control (group
DC), treatment with atorvastatin 20mg/kg (group DA), treatment with zinc sulfate 30mg/kg (group DZ)
and treatment with combination in half doses of both (group DZA)]. One month after treatment (orally),
animals were euthanized and serum levels of glucose and lipids were evaluated. At the end, the data
were analyzed by SPSS software, ANOVA and Tukey tests.
Results: The results of this study showed that treatment of diabetic rats with atorvastatin alone rather
than decreasing blood sugar, caused a significant decrease (p<0/05) in lipid, and treatment of diabetic
rats with zinc sulfate and combination in half doses of atorvastatin and zinc sulfate in addition to
significant reduction in glucose serum levels, caused significantly decrease in total cholesterol,
triglyceride, LDL and significant increase in HDL levels compared to the diabetic group.
Conclusion: It seems that combination of atorvastatin and zinc oxide have synergistic benefits in
controlling blood sugar levels and lipid profile and thus in controlling diabetes