GINGER HYDRO-ALCOHOLIC EXTRACT AMELIORATES THE ALCOHOL-INDUCED KIDNEY DYSFUNCTION IN RAT

Chronic alcohol administration decreases the renal tubular reabsorption and
induces renal dysfunction. The association between alcohol consumption and renal function, however,
is not very well known. The principal aim of this study was to investigate the effects of chronic
ethanol consumption on the functions of the kidney and the possible modification of this effect by
ginger extract.
Materials &Methods: Twenty-four male wistar rats were divided into three groups namely: Control,
ethanol (4.5 gr/kg BW by gavaj), and ginger extract treated ethanolic groups (4.5 gr/kg ethanol along
50 mg of ginger extract). Cystatin c, urea and creatinine in plasma were measured after 42 days.
Results: The results revealed that there was a significant decrease in glomerular filtration rate (GFR)
and also significant increase in plasma creatinine, urea and cystatin c in ethanol group compared to the
control group. Ginger extract treatment improved kidney disfunction induced by ethanol and it may be
due to the ginger antioxidant properties.
Conclusion: Ginger extract ameliorate kidney dysfunction induced by alcohol