ASSESSING AND COMPARING RESULT OF AMNIOCENTESIS AND TRIPLE MARKER TESTS TO DETECTION THE ANEUPLOIDIES

Antenatally detected of congenital abnormalities can prevent the bearing of
abnormal newborns that can create big problems for family and society. The aim of this study was
comparing the results of amniocentesis and triple marker tests.
Materials & Methods: This is a descriptive study which carried out in 2013. The participants in this
study consisted of 205 pregnant women at 15–20 weeks of pregnancy. The result of Down syndrome
and other Aneuploidy screening were high in these patients who referred to Alzahra hospital of Tabriz
for amniocentesis. A questionnaire including demographic, Down syndrome and triple marker test
information was used for data collection. Independent-Samples T-Test, Pearson test and One- Way
ANOVA were used for data analysis by applying SPSS /ver 13.
Results: The findings indicated that the mean (SD) age of participants was 33.9 ±4. AFP in 139
(68.5%) was lower than 1 MOM, Total βhcg in 68 (33.4%) was higher than 2 MOM, UE3 in 133
(65.5%) was lower than 1 MOM and Inhibin in 29 (31.2%) was higher than 2 MOM. Aneuploidy was
detected in 11 newborns (10 down syndrome, 1 Klinefelter's syndrome).There were significant
relationship between risk of Down syndrome and amniocentesis result (P= 0.0001). There weren't
significant relationship between NTD and trisomy 18 to amniocentesis result (P≥ 0.05). There were
significant relationship between age (P= 0.03), number of delivery (P= 0.04), number of children (P=
0.03) and prior abnormal child (P= 0.001) and amniocentesis results.
Conclusion: The results showed that the screening in first trimester can detected 11 newborns of
aneuploidies and it can prevent the stress of family, and invasive techniques (amniocentesis).So we
can use this way as a routine screening method