Protective effect of vitamin E against diabetes-induced oxidized LDL and aorta cell wall proliferation in rat

Hyperlipidemia and oxidized-low-density lipoproteins (Ox-LDL) are important independent
cardiovascular risk factors that have been shown to stimulate vascular smooth muscle cell (VSMC) proliferation.
The purpose of the present study was to investigate the effect of vitamin E on Ox-LDL, lipid profile, C-reactive
protein (CRP), and VSMC proliferation of rat aorta. Methods: Male Wistar rats (n = 32) were divided into four
groups namely: sham (SH), control (C), non-treated diabetic, and vitamin E-treated diabetic (VETD) groups. Ox-
LDL, lipid profile, CRP and VSMC proliferation of aorta were measured after 42 days. Results: The results
revealed that along with a significant increase in VSMC proliferation, the amount of CRP, Ox-LDL, and lipid
profiles in diabetic rats. VSMC proliferation was significantly ameliorated, and elevated CRP, Ox-LDL, and lipid
profiles were also restored to those of shams in VETD. Conclusions: These findings strongly support the idea that
diabetes induces Ox-LDL-mediated oxidative stress and VSMC proliferation in aorta of rat and imply that vitamin
E has a strong protective effect as an antioxidant