Quercetin: A functional dietary flavonoid with potential chemo-preventive properties in colorectal cancer

Recently, an intense attention has been paid to the application of natural
compounds as a novel therapeutic strategy for cancer treatment. Quercetin, a
natural flavonol present in many commonly consumed food items, is widely
demonstrated to exert inhibitory effects on cancer progression through various
mechanisms. Since there is a strong association with diets containing abundant
vegetables, fruits, and grains, and significant decline in the risk of colon cancer,
accumulation studies have focused on the anticancer potential of quercetin in
colorectal cancer. Cell cycle arrest, increase in apoptosis, antioxidant replication,
modulation of estrogen receptors, regulation of signaling pathways, inhibition of and
metastasis and angiogenesis are among various mechanisms underlying the chemopreventive effects of quercetin in colorectal cancer. This review covers various
therapeutic interactions of Quercetin as to how targets cellular involved in cancer
treatment.