The efficiency of transdermal insulin deliveryby using different concentrations of insulin ointment in hyperglycemic rats

Diabetes mellitus is one of the major issues of the healthcare systems of all societies. Patients with diabetes
mellitus type 1 (insulin-dependent diabetes) have to receive daily injections of insulin in order to maintain a constant normoglycemic
condition. Since this method of insulin delivery is so invasive and may end in a variety of mental and physical problems after its
long-term usage, many scientists have been trying to find less invasive ways of insulin delivery to these patients. At the present
study, the efficiency of transdermal insulin delivery using topical insulin ointment at different concentrations was investigated in
hyperglycemic rats.
Materials and Methods: For this purpose, 36 male rats were divided into six groups. The control group was delivered a combination
of Ketamin and Xylasine, and the rest were treated with different concentrations of insulin ointment following a Xylazine-induced
hyperglycemia, then the effect of the ointment on blood glucose levels was investigated.
Results: Our data showed that high concentration (1.73%) of insulin ointment can be as effective as injectable insulin in decreasing
blood glucose levels of hyperglycemic rats.
Conclusion: It is concluded that this way of insulin delivery can be a potential alternative to the conventional injectable method.
However, more studies are needed in order to confirm its quality and usage in human models