COMPARING THE SERUM TOTAL ANTIOXIDANT CAPACITY IN CHILDREN SUFFERING FROM HENOCH-SCHÖNLEIN PURPURA IN BOTH ACTIVE AND REMISSIVE PHASE OF THE ILLNESS

In recent studies it has been well documented that oxidative stress plays an active role in pathogenesis of many
diseases, including cardiovascular diseases, cancer, atherosclerosis and inflammatory disorders. On the other hand, HenochSchönleinpurpura which occurs in 10 out of one hundred thousand children is the most common child-time vasculitis; while the pathogenesis of the disease remains unknown, although it is generally considered a disease due to immunity complexes which is diagnosed
by the presence of immunity complexes containing immunoglobulin A in vessels, especially in those of skin, gastrointestinal tract, and
glomeruli. And it seems like oxidative stresses play a role indevelopment and clinical course of the illness. So far, few studies have been
undergone about the importance of oxidative stress and antioxidant status of the people in development, clinical course and the types
and severity of the symptoms of the illness.
Methodology: 48 patients, who were diagnosed suffering from Henoch-SchonleinPurpura and were hospitalized in nephrology
unit in Motahari hospital, in Orumieh, were studied.During routine blood sampling, serum samples were also taken to measure serum
total antioxidant capacity and they were kept at a temperature of minus 70 degree Celsius. Finally, the samples were tested by means
of FRAP method.
Results: 48 patients suffering from Henoch were included in the study. The serum total antioxidant capacity in acute phase was
significantly higher than that of recovery phase according to the results. Also, patients with higher organs involvement in their acute
phase, had a significantly higher serum total antioxidant capacity.
Conclusion: The results of this study suggest that oxidative stress plays an important role in pathogenesis and disease severity
in Henoch patients.