Investigation of Herpes Simplex Virus-2 (Hsv-2) Infection in Coronary Artery Disease Patients (CAD) in Population from Iran

Recent studies have suggested relationships between herpes simplex virus(HSV-2)infection and coronary artery disease
(CAD). Presented study investigated the association between the HSV-2immunoglobulin G (IgG) seropositivity, in
angiographically diagnosed coronary disease blood. In order to evaluation of Hsv-2 Infection In CAD Patients blood
samples were obtained from 193 CAD patients admitted for coronary angiography because of suspected coronary heart
disease. Lipid parameters and blood glucose level (fasting blood glucose and random blood glucose) were determined. Of
the 193 CAD patients, 192(99.49%) were positive by an ELISA method for herpes simplex virus-2 antibodies IgG and 1
(0.51%) were negative for Hsv-2IgG. When IgG antibodies were considered, there was significant correlation between
biochemical parameters and seropositivity of HSV-2 antibody in CAD patients. In conclusion, HSV-2 infection is more
common in CAD patients. Chronic HSV-2 infection may be associated with the development of atherosclerotic coronary
disease and viral treatment have effective role in control of advanced heart problems