Drug use evaluation of Meropenem at a tertiary care university hospital: A report from Northern Iran

The inappropriate use of antibiotics remains the primary factor in antimicrobial
drug resistance. In this study, we evaluate the use of meropenem in surgical/medical wards
of Imam Khomeini Tertiary Referral Hospital, Sari, Iran.
Methods: This retrospective observational study was used to assess rational use of
meropenem. The study was conducted by reviewing medical records of 100 admitted patients
who received meropenem during March 2013 to January 2014.
Findings: Meropenem was prescribed most frequently in Intensive Care Unit (22%), and
pneumonia was the most common diagnosis (35%). The third‑generation cephalosporins were
the most frequently prescribed antimicrobials after meropenem (53%). In 21% of the patients,
imipenem was changed to meropenem. Most of the inappropriate uses were seen in terms
of frequency of meropenem use (34%), followed by duration of meropenem therapy (28%).
Conclusion:Comparing our study results has shown higher inappropriate use. It is necessary
to take action to improve prescribing habit in order to reduce the unnecessary usage of
antibiotic thus enhance rational antibiotic use