Synergistic effects of hydro extract of jujube fruit in combination with Mesalazine (orally) and Asacol (intra-colonic) administration in ameliorating animal model of ulcerative colitis

This study was done to investigate the synergistic impacts hydro extract of jujube fruit in
combination with Mesalazine (orally) and Asacol (intra-colonic) administration in ameliorating animal model of ulcerative colitis (UC). After the induction of UC and with the
development of signs, the treatment groups daily received the hydro extract of jujube fruit
(200 mg/kg, orally, enema), Mesalazine (30 mg/kg, orally) and Asacol (10 mg/kg, enema). After
10 days, rats were euthanized and were studied. Findings indicated a significant increase
in Myeloperoxidase (161.66 ± 10.40), Nitric oxide (216.01 ± 17.55), IL-6 (138.54 ± 7.02), and
TNF- (123.87 ± 9.80) colon tissue levels and pathological damage of positive control group
compared with the negative control group. Hydro extract of jujube fruit in combination
with Mesalazine (orally) and Asacol (intra-colonic) group represented a higher capability
in significantly decreasing Myeloperoxidase (73.33 ± 9.07), Nitric oxide (81.66 ± 10.50), IL-6
(51.69 ± 5.19), TNF- (30.59 ± 5.50) levels and pathological damage in compared with the
other treatment groups. Considering accessibility and affordability of jujube fruit and the
side effects of routine drugs, taking a combination of jujube fruit with low doses of routine
pharmaceutical drugs can improve and cure ulcerative colitis disease.
Published by Elsevier Editora Ltda. on behalf of Sociedade Brasileira de Coloproctologia.
This is an open access article under the CC BY-NC-ND license