Determination of Serum Survivin for Prognostic Role in Esophageal Cancer

In the recent years, the considerable interest in survivin has significantly increased, because of its possible
detection role in esophageal cancer.
Materials and Methods: Twenty eight patients diagnosed with esophageal cancer and thirty three healthy controls were assessed for
the purpose of the study. From March 2015 until September 2017, the subjects who had esophageal cancer were enrolled in the study.
Blood samples were from subjects enrolled in a prospective cohort undergoing annual esophageal cancer testing. The concentrations
of serum survivin were determined using Elisa method.
Results: Serum levels of survivin in the esophageal patient group increased compared to the healthy controls [164.06±55.03 (mean±SD)
vs. 119.37±48.25, ng/L, P<0.04].Elevated serum survivin had positive correlation with clinical parameters.
Conclusion: The positive association between elevated serum survivin and esophageal cancer status could be due to the fact that this
protein involves in the development of esophageal cancer. Determination of serum survivin could differentiate normal and esophageal
cancer subjects and lead to lower numbers of excessive esophageal biopsies.