Targeting miRNAs by polyphenols: Novel therapeutic strategy for aging

Regarding the importance of genetic and epigenetic factors in regulation of aging process, different expression
pattern of non-coding RNAs in aging could be investigated. Accordingly, micro RNAs (miRNAs) with a wide
range of physiological functions as well as a significant footprint in many diseases have been demonstrated to be
down or upregulated during the aging process. Therefore, age‐associated microRNAs and their targets have
potentially detected the accelerated aging and predicted the risks for age‐related diseases. Polyphenols as im-
portant antioxidants in human dietary observed in fruits and some beverages have beneficial effects on longevity
and aging. Considering miRNAs as an interesting mediator in modulating polyphenols′ biological effects, tar-
geting miRNAs which is using polyphenols could be a novel strategy for aging.