Procalcitonin Testingreduce Unnecessary Antibiotic Use in Bacterial Infection

Conventional diagnostic test have limitations to deferential diagnosis in clinical suspicion ofbacterial infection
cases, that in some cases lead to inappropriate antibiotic therapy and increases antibiotic resistance. A new
diagnostic insight is procalcitonin (PCT) test to improve diagnosis of bacterial infections and to guide antibiotic
therapy. Serum PCT levels are of useful test as a biomarker in patients with bacterial infections for several
reasons. Initial rise of PCT levels due to bacterial infection, subsequent sequential PCT levels can be used to
assess the effectiveness and duration of antibiotic therapy. Based on clinical researches results, in bacterial
infections, promising good results obtained when use of PCT used as differential diagnostic test. But further
intervention studies are needed before use of PCT in clinical routine tests. The goal of this review is to study the
PCT reliability as infections diagnostic biomarker.