The Effect of Pregabalin on the Prevention of Succinylcholine-Induced Fasciculation and Myalgia

This study evaluates the effect of pregabalin on fasciculation and myalgia after using
succinylcholine.
Design: This randomized double-blind prospective study was conducted among 100 patients aged 20 to
60 years old.
Methods: Pregabalin (300 mg) and placebo (in capsule form) were placed in similar containers. The
results were analyzed by SPSS 23 software, and statistical analysis consisted of c
2 test and t test, and a
P value less than .05 was considered significant.
Findings: The mean pain score in the group receiving pregabalin was lower than the placebo group.
According to the c
2 test, there was a significant difference between the two groups in the frequency of
fasciculation (P ¼ .003). Mean fasciculation severity in the pregabalin group was lower than placebo
group. According to t test, there was a significant difference in the mean fasciculation severity between
the two groups (P ¼ .002).
Conclusions: This study showed that 300 mg of pregabalin was effective in reducing postoperative
fasciculation and myalgia in patients treated with succinylcholine