Eftekhari, A and Rameshrade, M and Hosseiniyan, S.M and Ardalan, M.R and Ahmadian, E and Derakhshankhah, H and Chodari, L and Jafari, S and Zununi Vahed, S and Kavetskyy, T (2020) Cell junction proteins: Crossing the glomerular filtration barrier in diabetic nephropathy. International Journal of Biological Macromolecules, 148. pp. 475-482.
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Abstract
Diabetic nephropathy as a deleterious complication of diabetes mellitus and an important cause of end-stage
renal failure is characterized by changes in the molecular and cellular levels. Cell-cell communication via the
gap and tight junctions are involved in the pathogenesis of diseases such as diabetes and kidney failure. Studying
cell junctions including gap junctions, tight junctions, and anchoring junctionswithin the nephron can be used as
an early sign of diabetic nephropathy. Furthermore, cell junctionsmay be an upcoming target by pharmacological
methods to improve treatments of diabetic nephropathy and pave the way to introduce promising therapeutic
strategies based on cell-cell communications effects and its translation into clinical studies for the treatment of
diabetic nephropathy.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Proteinuria Slit diagrams Podocytes Diabetic nephropathy Gap junctions Tight junctions |
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Unnamed user with email gholipour.s@umsu.ac.ir |
| Date Deposited: | 01 Feb 2020 09:03 |
| Last Modified: | 01 Feb 2020 09:03 |
| URI: | https://eprints.umsu.ac.ir/id/eprint/5831 |
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