Moghimi, S and Allahyari Devin, M and Hassanzadeh, M and Mahernia, SH and Pilali, H and Goli Garmroodi, F and Mahdavi, M and Amanlou, M and Firoozpour, L and Foroumadi, A.R (2018) Synthesis, evaluation, and molecular docking studies of aryl urea-triazole-based derivatives as anti-urease agents. Arch Pharm Chem Life Sci. pp. 1-8.
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Abstract
Considering the importance of urease inhibitors in the treatment of ureolytic
bacterial infections, in this work, the synthesis of novel, aryl urea-triazole-based
derivatives as effective urease inhibitors is described. Dichloro-substituted
derivative 4o, with IC50 =22.81±0.05μM, is found to be the most potent urease
inhibitor, determined by Berthelot colorimetric assay. Docking studies were also
carried out for compound 4o to confirm the effective interactions with the urease
active site.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | click reaction, docking study, triazole, urease |
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Unnamed user with email gholipour.s@umsu.ac.ir |
| Date Deposited: | 11 Apr 2020 06:22 |
| Last Modified: | 11 Apr 2020 06:22 |
| URI: | https://eprints.umsu.ac.ir/id/eprint/5909 |
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