ASSOCIATION OF ADIPONECTIN +45 T/G POLYMORPHISMWITH THE RISK OF POLYCYSTIC OVARY SYNDROME IN WOMEN FROM WEST AZERBAIJAN PROVINCE, IRAN

Polycystic ovary syndrome is the most common cause of infertility and is
characterized by the lack of ovulation and hyperandrogenism. The prevalence of polycystic ovary
syndrome among Iranian women is 14.6%. Several polycystic ovary syndrome susceptible gene variants
have been identified so far. The results of various studies are inconsistent. Due to drug side effects and
high cost of treatment, this study was designed to manage patients. In this study, the association of
adiponectin +45 T/G polymorphism with the risk of polycystic ovary syndrome in women from West
Azerbaijan Province (Iran) was evaluated.
Materials & Methods: This study was performed in two groups of patients and controls. 3 ml of
peripheral blood was collected from the participants in the study. Saturated salt method was used to
extract genomic DNA. PCR-RFLP method was used to determine polymorphisms.
Results: The mean age of the participants was 25.03±3.6 in the patient group and 27.01 ± 4.8 in the
control group. All the patients who participated in this study had average obesity with a body mass index
of 26.04±3.9. All patients were hirsute. In this study, no significant differences were observed between
the case and control groups regarding genotypic and allelic frequencies. The observed alleles and
genotypes of ADIPOQ +45 (T / G) were in Hardy-Weinberg equilibrium in the control group. Chi-
square and p-values with two degrees of freedom are 3.2 (<3.84) and 0.1, respectively.
Conclusion: ADIPOQ +45 (T / G) gene polymorphism is not a risk factor for polycystic ovary syndrome
in women of West Azerbaijan Province. Investigation of other risk factors related to genetic and
environmental factors and their interaction with each other is recommended.