EFFECT OF AEROBIC TRAINING ON THE FUNCTION OF HEPATIC SODIUM-DEPENDENT ASCORBATE TRANSPORTER TYPE 2 AND SERUM LEVELS OF HEPATIC TRANSAMINASES IN HEALTHY AND DIABETICWISTAR RATS: INTERVENTIONAL AND EXPERIMENTAL STUDY

Boyerahmadi, A and Behpour, N and Hosseinpour Delavar, S and Tadibi, V (2020) EFFECT OF AEROBIC TRAINING ON THE FUNCTION OF HEPATIC SODIUM-DEPENDENT ASCORBATE TRANSPORTER TYPE 2 AND SERUM LEVELS OF HEPATIC TRANSAMINASES IN HEALTHY AND DIABETICWISTAR RATS: INTERVENTIONAL AND EXPERIMENTAL STUDY. Studies in medical sciences 31 3 june 2020, 31 (3). pp. 199-208.

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Abstract

Sodium-dependent ascorbate transporter 2 (SVCT2) plays a key role in the
transmission of ascorbic acid to hepatocytes. The aim of this study was to compare the effect of aerobic
training on hepatic SVCT2 levels, serum levels of alanine aminotransferase (ALT), and aspartate
aminotransferase (AST) in diabetic rats.
Materials & Methods: In this interventional and experimental study, 25 maleWistar rats were randomly
divided into 5 groups: 1) healthy control, 2) healthy training, 3) diabetes control, 4) diabetes training,
and 5) sham. After Induction of diabetes, training program consisted of 6 weeks of running on the
treadmill, 5 sessions per week (for 20-40 minutes). Serum and liver tissues were evaluated to investigate
the effect of exercise training on ascorbic acid metabolism.
Results: Induction of diabetes significantly decreased serum and hepatic ascorbic acid levels and
significantly increased hepatic SVCT2 protein, ALT and AST serum levels (p <0.001). The results also
showed that regular aerobic exercise decreased serum glucose levels, serum levels of ALT and AST but
had no significant effect on serum hepatic and ascorbic acid levels and hepatic SVCT2.
Conclusion: According to the results of this study, induction of diabetes reduces hepatic ascorbic acid
levels, which seems to be associated with hyperglycemia and liver injury. On the other hand, six weeks
of aerobic exercise reduced blood glucose and liver transaminases, but had no significant effect on level
of serum, hepatic ascorbic acid, and hepatic SVCT2 levels.

Item Type: Article
Uncontrolled Keywords: Diabetes, Liver, Aerobic training, Sodium-dependent ascorbate transporter 2, Liver transaminases, Ascorbic acid
Subjects: R Medicine > R Medicine (General)
Depositing User: Unnamed user with email gholipour.s@umsu.ac.ir
Date Deposited: 04 Jul 2020 04:48
Last Modified: 04 Jul 2020 04:48
URI: https://eprints.umsu.ac.ir/id/eprint/5969

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