EVALUATION OF SERUM KLOTHO LEVEL IN PATIENTS WITH AND WITHOUT CORONARY ARTERY DISEASE

Serum Klotho is suggested to have a protective effect against cardiovascular diseases. Nitric oxide
production and preventing oxidative stress have been suggested as its possible mechanisms of action. In this study, we
aimed to evaluate the association between serum Klotho level and cardiovascular diseases.
Materials & Methods: According to coronary angiography results, 40 patients with a normal coronary artery and 40
patients with coronary artery disease were included in this study. Serum Klotho level and laboratory data were analyzed
for each patient and the association between serum Klotho level and coronary artery disease was evaluated.
Results: Our results showed that Serum Klotho level in patients with 1 vessel, 2 vessels, and 3 vessels disease was 2.16
0.2, 2.2 0.13, 1.98 0.2 mIU/L, respectively. (p =0.02) The plasma Klotho concentration was significantly lower in
patients with coronary artery disease.
Conclusion: Serum Klotho level can be a useful marker for the evaluation of patients with coronary artery disease.