THE EFFECT OF 8 WEEKS OF AEROBIC EXERCISE WITH NANO EUGENOL SUPPLEMENTATION ON INFLAMMATORY FACTORS OF TNF-A AND IL-1B AND HISTOLOGICAL CHANGES OF DORSAL ROOT GANGLION IN DIABETIC RATS

The aim of this study was to investigate the effect of 8 weeks of aerobic exercise
with Nano eugenol supplementation on inflammatory factors of TNF-a and IL-1B and histological
changes of dorsal root ganglion in diabetic rats.
Materials & Methods: 25 Wistar 8-week-old male rats were divided into 5 groups: Normal control
group, Diabetic control group (Model), Diabetic + exercise group (Model + Exe), Diabetic group + Nano
vaginal (Model + Nano), and Diabetic + exercise training + nano eugenol (Model + Exe + Nano). The
diabetes model was induced by peritoneal injection of streptozotocin to the respective groups. The
eugenol supplement was also gavaged to the supplement groups. Exercise groups also exercised for 8
weeks, 5 days a week (30 m / min).
Results: Induction of diabetes using STZ led to destruction of the tissue and cell alignment in the DRG
region. Gene changes also showed that TNF-a and IL-1B inflammatory factors showed a significant
increase in the DRG region in the diabetic group compared to the control group (p = 0.001 for both
variables). The study of therapeutic modalities also showed that only the diabetic + exercise +
nanougenol group showed a significant decrease in TNF-a compared to the diabetic group (p = 0.001).
Conclusion: According to the results of the present study, it seems that the use of nanougenol
supplementation along with exercise training may be effective in controlling the neurological damage
of diabetes by negatively regulating the inflammatory factor TNF-a, especially in the DRG region