OVERVIEW OF BIOLOGIC PRODUCTS WITH MARKETING AUTHORIZATION APPROVAL FOR CLINICAL APPLICATION

Among the different fields of modern medical sciences, regenerative medicine
has attracted the attention of many researchers and physicians. The development of this branch of
medicine has increased hopes for the treatment of incurable diseases. As a new idea in regenerative
medicine in interaction with tissue engineering and genetics, cell therapy has been able to snatch the
lead in modern medical sciences and confirm the clinical use of several cell-based pharmaceutical
products. Cell therapy aims to transplant healthy human cells to replace or repair damaged cells for
therapeutic purposes. Hence, this study aims to introduce and review approved cell-based drugs that are
currently used in therapy.
Materials & Methods: This study is a non-systematic review in which all biological products with
therapeutic approval worldwide were extracted and reported from relevant organizations' sites.
Articles were also searched manually and electronically in PubMed, Scopus, and Science Direct
databases.
Results: Since cell therapy products are related to products based on gene therapy and tissue
engineering, all biological products with clinical use approval were collected and introduced from
different countries. In total, the United States with 16 products, South Korea with 14 products, and the
European Union with 8 products had the highest number of cell therapy products, respectively.
Conclusion: Due to the novelty of this branch of medicine and the entry of cell therapy-based products
into the consumer market, a rising trend in production and attention to the future of reconstructive
medicine and cell therapy is predictable