Nanoparticle‑mediated synergistic chemoimmunotherapy for tailoring cancer therapy: recent advances and perspectives

Nowadays, a potent challenge in cancer treatment is considered the lack of efficacious strategy, which has not been
able to significantly reduce mortality. Chemoimmunotherapy (CIT) as a promising approach in both for the first-line
and relapsed therapy demonstrated particular benefit from two key gating strategies, including chemotherapy and
immunotherapy to cancer therapy; therefore, the discernment of their participation and role of potential synergies
in CIT approach is determinant. In this study, in addition to balancing the pros and cons of CIT with the challenges of
each of two main strategies, the recent advances in the cancer CIT have been discussed. Additionally, immunotherapeutic
strategies and the immunomodulation effect induced by chemotherapy, which boosts CIT have been brought
up. Finally, harnessing and development of the nanoparticles, which mediated CIT have expatiated in detail