Synthesis and characterization of novel hybrid nanomaterials based on β-cyclodextrine grafted halloysite nanotubes for delivery of doxorubicin to MCF-7 cell line

In the present study, the surface of halloysite nanotubes (Hal) grafted with a reactive β-cyclodextrin based monomer carrying vinyl carboxylic acid functional groups (MAH- β-CD) was designed and prepared through free radical copolymerization (Hal-V/MAH- β-CD) for anticancer drug delivery. Doxorubicin (DOX) was loaded effectively to the Hal-V/MAH- β-CD nanocarrier via physical adsorption with high loading efficiency. Drug release investigations demonstrated that DOX@ Hal-V/MAH- β-CD nanocarrier has a high drug release at cancerous condition (pH 5.4). From MTT assay, it was found that DOX@Hal-V/MAH- β-CD exerted great anticancer effect against MCF-7 breast cancer cells. The hemolysis experiments exhibited that nanocarrier has no remarkable hemolytic effect on human red blood cells (HRBCs), indicating the blood compatibility of the nanocarrier. Taken together, the newly prepared Hal-V/MAH- β-CD nanocarrier can be considered as a promising tool for DOX delivery to the MCF-7 breast cancer cells.