The therapeutic effects of chamomilla tincture mouthwash on oral aphthae: A randomized clinical trial

Introduction: Recurrent aphthous stomatitis (RAS) is a common clinical condition producing painful ulcerations in
the oral cavity. However, there has been no optimal therapeutic approach. Topical and systemic steroids commonly
prescribed for the condition have local and systemic side-effects. Recently, there is growing tendency toward herbal
medication in the modern society. The objective of this study was to assess the efficacy of a chamomilla mouth rinse
on reducing the signs and symptoms of aphthous lesions in comparison with a placebo mouth rinse.
Material and Methods: A randomized, triple-blind, placebo-controlled trial was performed on 36 patients, from
cases diagnosed with RAS, attending the Department of Oral Medicine, Mashhad University of Medical Sciences.
They were randomly divided into two groups: the intervention group(A), receiving chamomilla mouth rinse, and
the control group (B) receiving a placebo rinse. The ability of the solution to control the pain and burning sensation
and the number and size of the ulcers were evaluated.
Results: The number of ulcers in the 3rd visit (four days after treatment) showed a significant difference between
the groups (P<0.001). The pain and burning sensation (VAS) was reduced significantly in the test group in the 2nd
(p=0.001),3rd and 4th visit (P<0.001).
Conclusions: Chamomilla mouth rinse was effective in the treatment of RAS, controlling the pain and burning
sensation without producing any adverse side effects and can be advised as an alternative RAS treatment.