Vitamin D receptor taqi gene variant in exon 9 and polycystic ovary syndrome risk

Polycystic ovary syndrome (PCOS) is known as a metabolic disorder.
The results of recent studies implied that vitamin D receptor (VDR) genetic
variants may impact PCOS and insulin resistance in women with PCOS. The aim
of the present study was to determine the VDR TaqI gene variant in exon 9 (T/C)
(rs731236) in normal controls and patients with PCOS for the first time in Iranian
Azeri women.
Materials and Methods: In this case control study between April 2011 and June 2012,
a total of 76 women aged 18-40 years (38 patients with PCOS and 38 healthy women
as normal controls) participated. Genotypes of VDR TaqI in exon 9 (T/C) (rs731236)
were determined using the PCR-RFLP method.
Results: The frequencies of VDR TaqI T anc C alleles were 0.605 and 0.395 in cases
and 0.697 and 0.303 in controls. Also, the genotypic frequencies of VDR TaqI were
16) (42.11), 14(36.84), and 8(21.05) in cases, and 17(44.74), 19(50), and 2(5.26)
in controls for TT, TC and CC genotypes respectively. There was no difference in
genotype and allele frequencies between PCOS and controls (p value>0.05) with
the exception of the CC genotype (p value=0.04).
Conclusion: This report, a first of its own kind in Iranian Azeri patients, suggests that the
CC genotype of VDR TaqI in exon 9 (rs731236) is associated with PCOS