Co- transplantation of bone marrow stromal cells with schwann cells evokes mechanical allodynia in the contusion model of spinal cord injury in rats

Several studies have shown that, although transplantation of neural stem cells
into the contusion model of spinal cord injury (SCI) promotes locomotor function and improves
functional recovery, it induces a painful response, Allodynia. Different studies indicate
that bone marrow stromal cells (BMSCs) and Schwann cells (SCs) can improve
locomotor recovery when transplanted into the injured rat spinal cord. Since these cells
are commonly used in cell therapy, we investigated whether co-transplantation of these
cells leads to the development of Allodynia.