Saboory, E and Mohammadi, H and Dindarian, S and Mohammadi, S (2019) Prenatal stress and elevated seizure susceptibility: Molecular inheritable changes. Epilepsy & Behavior, 96. pp. 122-131.
|
Text
1452.pdf Download (1MB) | Preview |
Abstract
Stressful episodes are common during early-life and may have a wide range of negative effects on both physical and mental status of the offspring. In addition to various neurobehavioral complications induced by prenatal stress (PS), seizure is a common complication with no fully explained cause. In this study, the association between PS and seizure susceptibility was reviewed focusing on sex differences and various underlying mechanisms. The role of drugs in the initiation of seizure and the effects of PS on the nervous system that prone the brain for seizure, especially the hypothalamic–pituitary–adrenal (HPA) axis, are also discussed in detail by reviewing the papers studying the effect of PS on glutamatergic, gamma-aminobutyric acid (GABA)ergic, and adrenergic systems in the context of seizure and epilepsy. Finally, epigenetic changes in epilepsy are described, and the underlying mechanisms of this change are expanded. As the effects of PS may be life-lasting, it is possible to prevent future psychiatric and behavioral disorders including epilepsy by preventing avoidable PS risk factors
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Prenatal stress Early-life stages Seizure Epilepsy Long-lasting outcomes |
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Unnamed user with email gholipour.s@umsu.ac.ir |
| Date Deposited: | 29 Jul 2019 08:37 |
| Last Modified: | 29 Jul 2019 08:37 |
| URI: | http://eprints.umsu.ac.ir/id/eprint/5581 |
Actions (login required)
 |
View Item |
